Membrane potential and ionic content in pregnant and non-pregnant rat myometrium
نویسندگان
چکیده
منابع مشابه
Adenylyl cyclase isoforms in pregnant and non-pregnant human myometrium.
The precise factors involved in the transition of the relaxed pregnant uterus to the contractile state at the onset of parturition remain unclear, but it is accepted that cAMP-generating pathways contribute to uterine relaxation. We have previously reported an increased expression of the adenylyl cyclase (AC)-stimulating protein Galphas in human myometrium during gestation, with a corresponding...
متن کاملDifferential expression of ryanodine receptor RyR2 mRNA in the non-pregnant and pregnant human myometrium.
We describe here the expression of the ryanodine receptor isoforms RyR2 and RyR3 in human non-pregnant and pregnant (non-labouring) myometrium, and in isolated cultured myometrial cells. The mRNA encoding the RyR3 isoform was found in both non-pregnant and pregnant myometrial tissue samples; however, the mRNA for RyR2 was found only in pregnant samples. It can be speculated that the appearance ...
متن کاملExpression of G-protein-coupled receptor kinases in pregnant term and non-pregnant human myometrium.
There is evidence for hormonal receptor desensitisation in human myometrium, but little is known about the mechanisms involved in the loss of myometrial response to agonists such as beta(2)-adrenergic agonists, prostaglandin gamma and oxytocin. It is well known that the receptors for these hormones are coupled to G-proteins. The first step of receptor desensitisation is the phosphorylation of a...
متن کاملFunctional expression of purinergic P2X7 receptors in pregnant rat myometrium.
ATP has been reported to enhance the membrane conductance of myometrial cells and uterine contractility. Purinergic P2 receptor expression has been reported in the myometrium, using molecular biology, but the functional identity of the receptor subtype has not been determined. In this study, ATP-induced currents were recorded and characterized in single myometrial cells from pregnant rats using...
متن کاملPhasic Oscillations of Extracellular Potassium (Ko) in Pregnant Rat Myometrium
K-sensitive microelectrodes were used to measure K(+) within the extracellular space (K(o)) of pregnant rat myometrium. Contractile activity was monitored by measuring either force or bioelectrical signals. Single and double-barreled electrodes were used. Double-barreled electrodes allowed monitoring of electrical activity 15 microns from the site of K(o) measurement. From double-barreled elect...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 1965
ISSN: 0022-3751
DOI: 10.1113/jphysiol.1965.sp007591